منابع مشابه
Dmd052886 1763..1768
Rifampin causes drug interactions by altering hepatic drug metabolism. Because microRNAs (miRNAs) have been shown to regulate genes involved in drug metabolism, we determined the effect of rifampin on the expression of hepatic miRNAs. Primary human hepatocytes from seven subjects were treated with rifampin, and the expression of miRNA and cytochrome P450 (P450) mRNAs was measured by TaqMan assa...
متن کاملMathias Mayor (1775–1847)
Steno's inability to explain an affair of the soul such as pain in terms of the impact of matter reveals the dualist split between science and religion which makes itself increasingly perceptible at the time and seems to have troubled him fundamentally. Had earlier scientific men such as Harvey and Van Helmont been perhaps happier in their monist view of the world and of the 'working-matter' in...
متن کاملDmd065748 1847..1854
The mechanism by which drugs inhibit organic anion transporter 1 (OAT1) was examined. OAT1 was stably expressed in Chinese hamster ovary (CHO) cells, and para-aminohippurate (PAH) and 6-carboxyfluorescein were the substrates. Most compounds (10 of 14) inhibited competitively, increasing the Michaelis constant (Km) without affecting the maximal transport rate (Jmax). Others were mixed-type (lowe...
متن کاملPaul Langerhans, 1847-1888.
Time and history weave patterns with seemingly unrelated facts, as the weaver of a Persian rug blends varied threads through his loom to produce a design of ageless beauty. So it is with the facts of medical knowledge. Gathered and contributed by many workers, they may seem inconclusive or even insignificant at the time of their publication. But when they have been properly assembled and wisely...
متن کاملC1ob06688a 1847..1855 ++
The free energies of activation for the aryl–aryl rotation of 17 biphenyl derivatives, bearing a heavy heteroatom (S, Se, Te, P, Si, Sn) as ortho substituent, have been measured by variable temperature NMR. These numbers, so called B values, represent a meaningful measure of the steric hindrance exerted by the selected substituents. DFT computations match quite satisfactorily the experimental b...
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ژورنال
عنوان ژورنال: The Mississippi Valley Historical Review
سال: 1949
ISSN: 0161-391X
DOI: 10.2307/1895717